Publications

Key publications:

  1. Kuschyk J, Roeger S, Schneider R, et al. Efficacy and survival in patients with cardiac contractility modulation: Long-term single center experience in 81 patients. Int J Cardiol. 2015;183C:76-81. (link)
  2. Röger S, Michels J, Heggemann F, et al. Long term impact of cardiac contractility modulation on QRS duration. J Electrocardiol. 2014;47(6):936-40. (link)
  3. Giallauria F, Vigorito C, Piepoli MF, Stewart coats AJ. Effects of cardiac contractility modulation by non-excitatory electrical stimulation on exercise capacity and quality of life: an individual patient’s data meta-analysis of randomized controlled trials. Int J Cardiol. 2014;175(2):352-7. (link)
  4. Kuck KH, Bordachar P, Borggrefe M, et al. New devices in heart failure: an European Heart Rhythm Association report: developed by the European Heart Rhythm Association; endorsed by the Heart Failure Association. Europace. 2014;16(1):109-28. (link)
  5. Lyon AR, Samara MA, Feldman DS. Cardiac contractility modulation therapy in advanced systolic heart failure. Nat Rev Cardiol. 2013;10(10):584-98. (link)
  6. Borggrefe M, Burkhoff D. Clinical effects of cardiac contractility modulation (CCM) as a treatment for chronic heart failure. Eur J Heart Fail. 2012;14(7):703-12. (link)
  7. Abraham WT, Nademanee K, Volosin K, et al. Subgroup analysis of a randomized controlled trial evaluating the safety and efficacy of cardiac contractility modulation in advanced heart failure. J Card Fail. 2011;17(9):710-7. (link)
  8. Gupta RC, Mishra S, Rastogi S, et al. Ca(2+)-binding proteins in dogs with heart failure: effects of cardiac contractility modulation electrical signals. Clin Transl Sci. 2009;2(3):211-5. (link)
  9. Butter C, Rastogi S, Minden HH, Meyhöfer J, Burkhoff D, Sabbah HN. Cardiac contractility modulation electrical signals improve myocardial gene expression in patients with heart failure. J Am Coll Cardiol. 2008;51(18):1784-9. (link)
  10. Borggrefe MM, Lawo T, Butter C, et al. Randomized, double blind study of non-excitatory, cardiac contractility modulation electrical impulses for symptomatic heart failure. Eur Heart J. 2008;29(8):1019-28. (link)

Other publications (English):

  1. Abraham WT, Lindenfeld J, Reddy VY, et al. A randomized controlled trial to evaluate the safety and efficacy of cardiac contractility modulation in patients with moderately reduced left ventricular ejection fraction and a narrow QRS duration: study rationale and design. J Card Fail. 2015;21(1):16-23. (link)
  2. Röger S, Schneider R, Rudic B, et al. Cardiac contractility modulation: first experience in heart failure patients with reduced ejection fraction and permanent atrial fibrillation. Europace. 2014;16(8):1205-9. (link)
  3. Kahwash R, Burkhoff D, Abraham WT. Cardiac contractility modulation in patients with advanced heart failure. Expert Rev Cardiovasc Ther. 2013;11(5):635-45. (link)
  4. Burri H, Bordachar P. Cardiac contractility modulation for treatment of heart failure. Cardiovas Med. 2013;16(10):259-62 (link)
  5. Goliasch G, Khorsand A, Schütz M, et al. The effect of device-based cardiac contractility modulation therapy on myocardial efficiency and oxidative metabolism in patients with heart failure. Eur J Nucl Med Mol Imaging. 2012;39(3):408-15. (link)
  6. Jorge J, Noble A. The Economic Benefit of Cardiac Contractility Modulation Therapy for Heart Failure Patients in the United Kingdom. A Market Research Project. 2012 (unpublished)
  7. Burkhoff D. Does contractility modulation have a role in the treatment of heart failure?. Curr Heart Fail Rep. 2011;8(4):260-5. (link)
  8. Schau T, Seifert M, Meyhöfer J, Neuss M, Butter C. Long-term outcome of cardiac contractility modulation in patients with severe congestive heart failure. Europace. 2011;13(10):1436-44. (link)
  9. Kadish A, Nademanee K, Volosin K, et al. A randomized controlled trial evaluating the safety and efficacy of cardiac contractility modulation in advanced heart failure. Am Heart J. 2011;161(2):329-337.e1-2. (link)
  10. D Burkhoff, HN Sabbah, C Butter, Y Mika and M Borggrefe. Cardiac contractility modulation by electrical signals applied during the absolute refractory period as a treatment for chronic heart failure. Heart Failure Device Management. Edited by AM Feldman. 2010;44-58
  11. Yu CM, Chan JY, Zhang Q, et al. Impact of cardiac contractility modulation on left ventricular global and regional function and remodeling. JACC Cardiovasc Imaging. 2009;2(12):1341-9. (link)
  12. Gupta RC, Mishra S, Wang M, et al. Cardiac contractility modulation electrical signals normalize activity, expression, and phosphorylation of the Na+-Ca2+ exchanger in heart failure. J Card Fail. 2009;15(1):48-56. (link)
  13. Nägele H, Behrens S, Eisermann C. Cardiac contractility modulation in non-responders to cardiac resynchronization therapy. Europace. 2008;10(12):1375-80. (link)
  14. Abraham WT, Burkhoff D, Nademanee K, et al. A randomized controlled trial to evaluate the safety and efficacy of cardiac contractility modulation in patients with systolic heart failure: rationale, design, and baseline patient characteristics. Am Heart J. 2008;156(4):641-648.e1. (link)
  15. Rastogi S, Mishra S, Zacà V, Mika Y, Rousso B, Sabbah HN. Effects of chronic therapy with cardiac contractility modulation electrical signals on cytoskeletal proteins and matrix metalloproteinases in dogs with heart failure. Cardiology. 2008;110(4):230-7. (link)
  16. Butter C, Meyhöfer J, Seifert M, Neuss M, Minden HH. First use of cardiac contractility modulation (CCM) in a patient failing CRT therapy: clinical and technical aspects of combined therapies. Eur J Heart Fail. 2007;9(9):955-8. (link)
  17. Imai M, Rastogi S, Gupta RC, et al. Therapy with cardiac contractility modulation electrical signals improves left ventricular function and remodeling in dogs with chronic heart failure. J Am Coll Cardiol. 2007;49(21):2120-8. (link)
  18. Butter C, Wellnhofer E, Schlegl M, Winbeck G, Fleck E, Sabbah HN. Enhanced inotropic state of the failing left ventricle by cardiac contractility modulation electrical signals is not associated with increased myocardial oxygen consumption. J Card Fail. 2007;13(2):137-42. (link)
  19. Neelagaru SB, Sanchez JE, Lau SK, et al. Nonexcitatory, cardiac contractility modulation electrical impulses: feasibility study for advanced heart failure in patients with normal QRS duration. Heart Rhythm. 2006;3(10):1140-7. (link)
  20. Sabbah HN, Gupta RC, Rastogi S, Mishra S, Mika Y, Burkhoff D. Treating heart failure with cardiac contractility modulation electrical signals. Curr Heart Fail Rep. 2006;3(1):21-4. (link)
  21. Brunckhorst CB, Shemer I, Mika Y, Ben-haim SA, Burkhoff D. Cardiac contractility modulation by non-excitatory currents: studies in isolated cardiac muscle. Eur J Heart Fail. 2006;8(1):7-15. (link)
  22. Lawo T, Borggrefe M, Butter C, et al. Electrical signals applied during the absolute refractory period: an investigational treatment for advanced heart failure in patients with normal QRS duration. J Am Coll Cardiol. 2005;46(12):2229-36. (link)
  23. Burkhoff D, Ben-haim SA. Nonexcitatory electrical signals for enhancing ventricular contractility: rationale and initial investigations of an experimental treatment for heart failure. Am J Physiol Heart Circ Physiol. 2005;288(6):H2550-6. (link)
  24. Augello G, Santinelli V, Vicedomini G, et al. Cardiac contractility modulation by non-excitatory electrical currents. The new frontier for electrical therapy of heart failure. Ital Heart J. 2004;5 Suppl 6:68S-75S. (link)
  25. Stix G, Borggrefe M, Wolpert C, et al. Chronic electrical stimulation during the absolute refractory period of the myocardium improves severe heart failure. Eur Heart J. 2004;25(8):650-5. (link)
  26. Pappone C, Augello G, Rosanio S, et al. First human chronic experience with cardiac contractility modulation by nonexcitatory electrical currents for treating systolic heart failure: mid-term safety and efficacy results from a multicenter study. J Cardiovasc Electrophysiol. 2004;15(4):418-27. (link)
  27. Morita H, Suzuki G, Haddad W, et al. Long-term effects of non-excitatory cardiac contractility modulation electric signals on the progression of heart failure in dogs. Eur J Heart Fail. 2004;6(2):145-50. (link)
  28. Mohri S, Shimizu J, Mika Y, et al. Electric currents applied during refractory period enhance contractility and systolic calcium in the ferret heart. Am J Physiol Heart Circ Physiol. 2003;284(4):H1119-23. (link)
  29. Morita H, Suzuki G, Haddad W, et al. Cardiac contractility modulation with nonexcitatory electric signals improves left ventricular function in dogs with chronic heart failure. J Card Fail. 2003;9(1):69-75. (link)
  30. Pappone C, Rosanio S, Burkhoff D, et al. Cardiac contractility modulation by electric currents applied during the refractory period in patients with heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol. 2002;90(12):1307-13. (link)
  31. Mohri S, He KL, Dickstein M, et al. Cardiac contractility modulation by electric currents applied during the refractory period. Am J Physiol Heart Circ Physiol. 2002;282(5):H1642-7. (link)
  32. Sabbah HN, Haddad W, Mika Y, et al. Cardiac contractility modulation with the impulse dynamics signal: studies in dogs with chronic heart failure. Heart Fail Rev. 2001;6(1):45-53. (link)
  33. Pappone C, Vicedomini G, Salvati A, et al. Electrical modulation of cardiac contractility: clinical aspects in congestive heart failure. Heart Fail Rev. 2001;6(1):55-60. (link)
  34. Burkhoff D, Shemer I, Felzen B, et al. Electric currents applied during the refractory period can modulate cardiac contractility in vitro and in vivo. Heart Fail Rev. 2001;6(1):27-34. (link)
  35. Callans DJ, Fuchs S, Mika Y, et al. Global improvement in left ventricular performance observed with cardiac contractility modulation is the result of changes in regional contractility. Heart Fail Rev. 2001;6(1):35-44. (link)